Dysbiosis of gut microbiota
The intestinal microbiota becomes imbalanced with age, leading to chronic inflammation and compromised immunity.
Enabling cellular nutrition through scientific research and development
The physiological state of the organism is a natural physiological process that can be studied and regulated through nutritional means. Understanding the physiological state of the body and the mechanisms by which AKG components exert their effects, as well as recognizing the unique characteristics of the SDAI formulation, is essential.
What is biological age?
Chronological age
Just a number — it records how long you've been here, but says nothing about your body's true state.
Biological age
It writes your true life story — predicting long-term health and lifespan more accurately than your birth date.
How biological age is assessed:
DNA methylation
Epigenetic clock
Inflammation level
Chronic inflammation load
Cellular repair capacity
Damage-repair efficiency
Mitochondrial function
Cellular energy output
Biological age predicts long-term health and lifespan more accurately than birth date — the very metric SDAI focuses on and works to optimize.
How does AKG help maintain an ideal body condition?
α-Ketoglutarate (AKG) is a crucial molecule involved in cellular metabolism and epigenetic regulation, providing essential support for cellular physiological functions.
Mitochondrial energy core
AKG is a crucial component for mitochondrial function and participates in the body's daily energy production process.
De-methylating key coenzyme
As an important coenzyme in DNA and histone demethylation, it participates in normal cellular physiological regulatory processes.
Maintains homeostasis of the organism
Participates in the body's physiological regulatory processes, helping to maintain a stable and comfortable daily state.
Why doesn't ordinary AKG work?
The key to supplementing AKG isn't “whether you take it,” but “whether your body can actually keep using it.”
Breaks down too fast
Ordinary AKG has just a 5-minute half-life and is fully metabolized within 30 minutes — an extremely short window.
Low bioavailability
Most is destroyed in the stomach's acidic environment, so very little actually enters circulation to act.
Low raw-material purity
Ordinary AKG on the market is often below 78% purity, with impurities that further hurt absorption and safety.
No controlled-release technology
Without steady, sustained action, concentrations spike and crash, making stable physiological effects hard to maintain.
12 biological mechanisms underlying aging
12 Biological Mechanisms Behind Aging – Also Key Targets for Extending Healthy Life Span
Stem cell depletion
The reduction in available stem cells leads to a corresponding decline in tissue repair and regeneration capacity.
chronic inflammation
Persistent mild "inflammatory aging" damages tissues and accelerates various age-related diseases.
cell ageing
Senescent cells cease dividing but do not die, releasing harmful inflammatory signals that contaminate surrounding tissues.
Epigenetic alterations
Chemical markers used for gene regulation undergo drift, disrupting cellular identity and function.
Mitochondrial dysfunction
The efficiency of the cells "energy factory" declines, leading to increased production of free radicals and waste products.
Disruption of nutrient sensing
Disruptions in signaling pathways such as mTOR and AMPK lead to imbalances in metabolism and stress responses.
Genomic instability
Accumulated DNA damage leads to mutations, loss of function, and increased disease risk.
Changes in intercellular communication
Disruption of intercellular signaling, decreased coordination among organ systems, and elevated inflammatory levels.
Telomere shortening
The chromosomal protective cap shortens during cell division, ultimately rendering the cell incapable of further division.
Dysfunction of autophagy
The cells "cleaning system" slows down, preventing timely recycling of damaged components.
Loss of protein homeostasis
Protein mis folding and aggregation are closely associated with neurodegenerative diseases.
Longevity Library
Curated explainers on cutting-edge longevity science and related literature, continuously updated.
AKG can reduce human biological age by 5.74 years
A saliva-based DNA epigenetic cohort study involving 4,260 participants analyzed the associations between 84 dietary supplements and physiological biomarkers. The study demonstrated that a sustained-release calcium–α-ketoglutarate multivitamin formulation could induce a positive shift in age residuals by 5.74 years; these findings require further validation through subsequent controlled studies.
AKG Supports Muscle Health, Recovery, and Endurance
This review explores AKG’s role in preventing muscle atrophy and enhancing regeneration. In preclinical and human studies, AKG improves satellite cell proliferation and muscle repair, reduces inflammation through macrophage polarization, and enhances endurance and recovery in active individuals. It also activates mTOR and boosts energy production under stress, highlighting its relevance for aging muscle, injury recovery, and performance support.
The Antioxidative Function of AKG and Its Applications
AKG directly scavenges reactive oxygen species (ROS) like hydrogen peroxide, converting them into harmless byproducts through oxidative decarboxylation. It also fuels ATP production via the TCA cycle and promotes synthesis of glutamine and glutamate, critical to redox balance. Studies show AKG reduces oxidative stress across organs including brain, liver, and gut—highlighting its therapeutic potential in aging and inflammation-related disorders.
AKG Extends Lifespan and Healthspan in Mice
In two large cohorts of middle-aged mice, dietary CaAKG extended lifespan (up to 20% in females) and compressed morbidity—delaying frailty more than it extended life. Mice showed lower inflammation, increased IL-10 production (a key anti-inflammatory cytokine), improved coat condition, and better gait. These findings support AKG’s role in modulating age-related inflammatory signaling (SASP) without eliminating senescent cells.